γ-H2AX and other histone post-translational modifications in the clinic
نویسندگان
چکیده
منابع مشابه
Lysine post-translational modifications and the cytoskeleton.
PTMs (post-translational modifications) of lysine residues have proven to be major regulators of gene expression, protein-protein interactions, and protein processing and degradation. This is of particular importance in regulating the cytoskeleton, an enormously complex system of proteins responsible for cell motility, intracellular trafficking, and maintenance of cell form and structure. The c...
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Malaria is one of the most important human parasitic diseases in the world, affecting about 400 million people and killing about 1 million children every year. Our relationship with the malarial parasite has been a long one on the evolutionary scale, and the methods adopted by the parasite to thrive and colonize our bodies are truly fascinating. In order to control the disease, it is of fundame...
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The presence of phosphorylated histone H2AX (γ-H2AX) is associated with the local activation of DNA-damage repair pathways. Although γ-H2AX deregulation in cancer has previously been reported, the molecular mechanism involved and its relationship with other histone modifications remain largely unknown. Here we find that the histone methyltransferase SUV39H2 methylates histone H2AX on lysine 134...
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Microtubules are the largest filamentous components of the eukaryotic cytoskeleton. In spite of their extraordinary level of structural conservation, microtubules fulfill a vast range of different functions in cells. How this functional diversity is achieved remains an open question; however, recent advances point towards post-translational modifications (PTMs) of tubulin as a potent mechanism ...
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Histone variants are chromatin components that replace replication-coupled histones in a fraction of nucleosomes and confer particular characteristics to chromatin. H2A variants represent the most numerous and diverse group among histone protein families. In the nucleosomal structure, H2A-H2B dimers can be removed and exchanged more easily than the stable H3-H4 core. The unstructured N-terminal...
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ژورنال
عنوان ژورنال: Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms
سال: 2012
ISSN: 1874-9399
DOI: 10.1016/j.bbagrm.2012.02.021